IL-6 mediated JAK/STAT3 signaling pathway in cancer patients with cachexia


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Eskiler G. G., Bezdegumeli E., Ozman Z., Ozkan D. A., Bilir C., Kucukakca B. N., ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.120, no.11, pp.819-826, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 120 Issue: 11
  • Publication Date: 2019
  • Doi Number: 10.4149/bll_2019_136
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.819-826
  • Keywords: cachexia, IL-6, STAT3, gastric cancer, lung cancer, breast cancer, BREAST-CANCER, SKELETAL-MUSCLE, INFLAMMATORY CYTOKINES, INTERLEUKIN-6, GENES, SUSCEPTIBILITY, POLYMORPHISMS, DYSREGULATION, CROSSROADS, AXIS
  • Bezmialem Vakıf University Affiliated: No

Abstract

OBJECTIVES: We investigated the changes in the IL-6 and STAT3 expression levels in cachectic and non-cachectic patients with gastric, lung and breast cancer and evaluated the association between IL-6 and STAT3 levels and cancer types in terms of cachexia condition. BACKGROUND: Cancer-associated cachexia, observed in nearly 50.80 % of cancer patients, has drawn attention in advanced patients. IL-6/JAK/STAT pathway plays an essential role in the progression of cancer cachexia through the regulation of the inflammatory response.