Prognostic evidence of LEF1 isoforms in childhood acute lymphoblastic leukemia.


Erbilgin Y., Hatirnaz Ng O., Can I., Firtina S., Kucukcankurt F., Karaman S., ...More

International journal of laboratory hematology, vol.43, pp.1093-1103, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43
  • Publication Date: 2021
  • Doi Number: 10.1111/ijlh.13513
  • Journal Name: International journal of laboratory hematology
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.1093-1103
  • Keywords: ALL, biomarker, gene expression, LEF1, prognosis

Abstract

Introduction The lymphoid enhancer factor 1 (LEF1) is a DNA-binding transcription factor that functions in the Wnt signaling pathway. Increased LEF1 activity is associated with progression of several types of cancer including leukemia. Here, we investigated LEF1 isoform expression and genomic variations in acute lymphoblastic leukemia (ALL).