Diterpenes from the berries of Juniperus excelsa

Topcu G., ERENLER R., CAKMAK O., JOHANSSON C., CELIK C., CHAI H., ...More

PHYTOCHEMISTRY, vol.50, no.7, pp.1195-1199, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 7
  • Publication Date: 1999
  • Doi Number: 10.1016/s0031-9422(98)00675-x
  • Journal Name: PHYTOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1195-1199
  • Keywords: Juniperus excelsa, Cupressaceae, berries, diterpenes, juniperexcelsic acid, sesquiterpene, cytotoxic, antituberculosis and antibacterial activity
  • Bezmialem Vakıf University Affiliated: No

Abstract

From the hexane extract of berries of Juniperus excelsa, one new and four known diterpenes were isolated besides a known sesquiterpene. The structures of the known diterpenes were identified as isopimaric, isocommunic, (-)ent-trans communic and sandracopimaric acids, along with the sesquiterpene 4a-hydroxycedrol and the new compound which was elucidated as 3 alpha-acetoxylabda-8(17), 13(16), 14-trien-19-oic acid (juniperexcelsic acid). Cytotoxic activity of the hexane extract was investigated against a panel of cell line and found highyl active against LNCaP, KB-V (+VLB) and KB-V (-VLB) cell lines. Furthermore, the hexane and methanol extracts, and the new compound were found to be moderately active against Mycobacterium tuberculosis. (C) 1999 Elsevier Science Ltd. All rights reserved.