No Harmful Effect of Dialysis-Induced Hypotension on the Myocardium in Patients Who Have Normal Ejection Fraction and a Negative Exercise Test

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Fotbolcu H., Oduncu V., Gurel E., Cevik C., Erkol A., Ozden K., ...More

KIDNEY & BLOOD PRESSURE RESEARCH, vol.35, no.6, pp.671-677, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1159/000342755
  • Journal Name: KIDNEY & BLOOD PRESSURE RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.671-677
  • Keywords: Dialysis-induced hypotension, Biventricular systolic and diastolic functions, Ejection fraction, STAGE RENAL-DISEASE, LEFT-VENTRICULAR DYSFUNCTION, CORONARY FLOW RESERVE, HEMODIALYSIS-PATIENTS, ECHOCARDIOGRAPHIC ASSESSMENT, MAINTENANCE HEMODIALYSIS, CARDIOVASCULAR-DISEASE, CARDIAC DYSFUNCTION, FAILURE, THERAPY
  • Open Archive Collection: AVESIS Open Access Collection
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: We investigated the effects of dialysis-induced hypotension (DIH) on the myocardium of patients who have a normal ejection fraction and normal treadmill stress tests. Methods: This study included 26 end-stage renal disease (ESRD) patients with DIH, 30 ESRD patients without DIH (non-DIH), and 30 control subjects. Mitral-myocardial systolic velocity (MSV), the mitral E'/A' ratio, the left ventricle filling pressure index (E/E' ratio), tricuspid-MSV, and the tricuspid E'/A' ratio were calculated. Results: Biventricular systolic and diastolic functions were impaired in dialysis patients. The mitral and tricuspid MSV were similar between DIH and non-DIH patients (8.03 +/- 0.90 cm/s vs. 8.31 +/- 1.68 cm/s, p = 0.896, and 13.27 +/- 2.97 cm/s vs. 13.15 +/- 2.37 cm/s, p = 0.980). Mitral and tricuspid E'/A' were similar between DIH and non-DIH patients. (1.30 +/- 0.53 vs. 1.16 +/- 0.56, p = 0.695, and 0.70 +/- 0.24 vs. 0.68 +/- 0.33, p = 0.976). Likewise, the E/E' ratio was similar between DIH and non-DIH patients (8.20 +/- 2.83 vs. 8.28 +/- 2.53, p = 0.990). Conclusion: Although biventricular systolic and diastolic function is impaired in dialysis patients compared to controls, DIH episodes did not have an adverse effect on the myocardial functions. Copyright (C) 2012 S. Karger AG, Basel