Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus

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KHAN M. A., Heiny A. T., Lee K. X., Srinivasan K. N., Tan T. W., August J. T., ...More

BMC BIOINFORMATICS, vol.7, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2006
  • Doi Number: 10.1186/1471-2105-7-s5-s4
  • Journal Name: BMC BIOINFORMATICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Bezmialem Vakıf University Affiliated: No

Abstract

Background: Antigenic diversity in dengue virus strains has been studied, but large-scale and detailed systematic analyses have not been reported. In this study, we report a bioinformatics method for analyzing viral antigenic diversity in the context of T-cell mediated immune responses. We applied this method to study the relationship between short-peptide antigenic diversity and protein sequence diversity of dengue virus. We also studied the effects of sequence determinants on viral antigenic diversity. Short peptides, principally 9-mers were studied because they represent the predominant length of binding cores of T-cell epitopes, which are important for formulation of vaccines.