Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the A beta((1-42))-infused rat model of Alzheimer's disease


ELİBOL B. , Terzioglu-Usak Ş. , BEKER M. , Sahbaz C.

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.29, no.4, pp.379-386, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1080/24750573.2019.1673945
  • Title of Journal : PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Page Numbers: pp.379-386
  • Keywords: Thymoquinone, Alzheimer's disease, neuroinflammation, Magnetic Luminex assay, Western blotting, MICROTUBULE-ASSOCIATED PROTEIN-2, BRAIN OXIDATIVE STRESS, AMYLOID-BETA PEPTIDE, IFN-GAMMA, HIPPOCAMPAL NEUROGENESIS, SUSTAINED IL-1-BETA, NIGELLA-SATIVA, DENSE-CORE, A-BETA, MEMORY

Abstract

OBJECTIVES: Alzheimer's disease (AD) is a severe neurodegenerative disease with presentation of the neuronal death, memory loss and cognitive decline. The relationship between neuroinflammation and AD has been well documented. However, the options of anti-inflammatory treatment are very limited in patients with AD. Previous studies showed that flavonoids might be an effective treatment and thymoquinone (TQ), an aromatic hydrocarbon found in Nigella sativa suggested as a candidate molecule due to having strong anti-inflammatory effects. Our study aimed to investigate the effects of TQ on neuroinflammation and neuroprotection in A beta((1-42)) infused rat model of AD.