Peri-operative radiotherapy for the prevention of post-operative fibrosis on rats


KIZILTAN H. Ş. , ERIS A. H. , MERAL İ. , SEYİTHANOĞLU H., DÜNDAR T. T. , EREN F., et al.

INTERNATIONAL JOURNAL OF RADIATION RESEARCH, cilt.16, ss.481-485, 2018 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 16 Konu: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.18869/acadpub.ijrr.16.4.481
  • Dergi Adı: INTERNATIONAL JOURNAL OF RADIATION RESEARCH
  • Sayfa Sayısı: ss.481-485

Özet

Background: Post-operative fibrosis related pains and functional anomalies can be serious problems for patients. Radiotherapy (RT) could inhibit fibrosis which may occurs post- operation especially following laminectomy. Therefore, this study was designed to investigate the effect of peri-operative RT on the prevention of post-operative fibrosis and scar formation on rats. Materials and Methods: Twenty three male Wistar albino rats, were divided into three experimental groups. Laminectomy was performed to L3 and L4 lomber vertebral regions of group L and L+R rats. The rats in L+R group in addition to this procedure also received ped-operative RT on the laminectomy area. A total dose of 700 cGy of RT was applied as a single fraction using electrons. Control rats received no treatment. A rotarod test was performed at 20, 30 and 40 rpm/min speed rates to determine the physical performances of the rats. Results: The results have indicated statistically significant (P<0.05) differences for the 30 rpm/min rotarod test between the L and L+R groups. Histopatologically, significant differences were observed in epidural fibrosis, fibroblast cell density and arachnoid adhesion between the L and L+R groups. Conclusion: It was concluded that ped-operative RT may provide a significant advantage for prevention post-laminectomic of scar tissue formation.