Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery

YAMAÇ, AYLİN; Kucukbuzcu, Sitki; OZANSOY, MEHMET; Gok, Ozlem; Oz, Kursat; Erturk, Mehmet; Yilmaz, Emre; Ersoy, Burak; ZEYBEK, RAHMİ; Goktekin, Omer; Kilic, Ulkan

doi:10.1016/j.carpath.2016.02.002

Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery

YAMAÇ A. H., Kucukbuzcu S., OZANSOY M., Gok O., Oz K., Erturk M., ...More

CARDIOVASCULAR PATHOLOGY, vol.25, no.3, pp.232-236, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 25 Issue: 3
Publication Date: 2016
Doi Number: 10.1016/j.carpath.2016.02.002
Journal Name: CARDIOVASCULAR PATHOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.232-236
Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Postoperative atrial fibrillation (POAF) is a potentially life-threatening complication after coronary artery bypass graft (CABG) surgery. The expression of the cardioprotective SIRT1 protein with its antioxidant activity is increased in cardiac tissue of patients suffering from POAF. So far, information is lacking about the relationship between SIRT1 regulating micro RNAs (miRs), SIRT1 protein and the occurrence of POAF.