Retrospective Analyzes of Extrapulmonary Tuberculosis Cases

Gurmanı R., Akkoyunlu Y., Durdu B., Okay G., Sümbül B., Aslan T.

International Congress of Antimicrobial Chemotherapy (ICC), İstanbul, Türkiye, 3 - 06 Kasım 2024, ss.61, (Tam Metin Bildiri)

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Doi Numarası: 10.1016/j.jgar.2024.10.193
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.61
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

AIM

To analyze demographic and clinical characteristics of extrapulmonary tuberculosis(EPTB) cases retrospectively.

BACKGROUND

EPTB may affect all organs also the lungs and presents with a wide range of symptoms, making diagnosis challenging.

METHOD

A retrospective analysis was conducted on adult EPTB-diagnosed patients at Bezmialem Vakıf University from 2013 to 2024. Data on patient demographics, clinical presentations, diagnostic methods, and outcomes were analyzed.

RESULTS

Among 249 patients, 89(35.7%) were male, and 160(64.3%) were female. The mean age of male patients was 44.1±19.8 years, while female patients had a mean age of 45.9±15.8 years. 10.8% of the patients were foreign nationalities. Previous exposure to Mycobacterium tuberculosis was present in 7.6% of patients, and 6.8% had history of previous TB infection. EPTB involvement was as follows: lymph nodes in 107(43.0%), pleura in 19(7.6%), other in 24(9.6%), urogenital system in 17(6.8%), sykeletal system in 29(11.6%), central nervous system in 19(7.6%), peritoneum in 24(9.6%), and skin in 10(4.0%). Cervical lymph nodes were the most frequently affected region, observed in 48 cases (19.3%). Acid-fast bacilli were identified in 13(5.2%) of 141 samples, Mycobacterium tuberculosis grew in culture of 57(22.9%) of 148 samples, and the polymerase chain reaction was positive for tuberculosis in 21(8.4%) of 84 samples. QuantiFERON was positive in 18.9% of patients.

CONCLUSİON

For diagnosing EPTB, it's essential to maintain a high level of clinical suspicion and to use a combination of diagnostic methods, including mycobacterial culture and PCR and also pathological examination.

AIM

To analyze demographic and clinical characteristics of extrapulmonary tuberculosis(EPTB) cases retrospectively.

BACKGROUND

EPTB may affect all organs also the lungs and presents with a wide range of symptoms, making diagnosis challenging.

METHOD

A retrospective analysis was conducted on adult EPTB-diagnosed patients at Bezmialem Vakıf University from 2013 to 2024. Data on patient demographics, clinical presentations, diagnostic methods, and outcomes were analyzed.

RESULTS

Among 249 patients, 89(35.7%) were male, and 160(64.3%) were female. The mean age of male patients was 44.1±19.8 years, while female patients had a mean age of 45.9±15.8 years. 10.8% of the patients were foreign nationalities. Previous exposure to Mycobacterium tuberculosis was present in 7.6% of patients, and 6.8% had history of previous TB infection. EPTB involvement was as follows: lymph nodes in 107(43.0%), pleura in 19(7.6%), other in 24(9.6%), urogenital system in 17(6.8%), sykeletal system in 29(11.6%), central nervous system in 19(7.6%), peritoneum in 24(9.6%), and skin in 10(4.0%). Cervical lymph nodes were the most frequently affected region, observed in 48 cases (19.3%). Acid-fast bacilli were identified in 13(5.2%) of 141 samples, Mycobacterium tuberculosis grew in culture of 57(22.9%) of 148 samples, and the polymerase chain reaction was positive for tuberculosis in 21(8.4%) of 84 samples. QuantiFERON was positive in 18.9% of patients.

CONCLUSİON

For diagnosing EPTB, it's essential to maintain a high level of clinical suspicion and to use a combination of diagnostic methods, including mycobacterial culture and PCR and also pathological examination.