Hippocampal (1)H MRS in patients with bipolar disorder taking valproate versus valproate plus quetiapine

Atmaca M., Yildirim H., Ozdemir H., Ogur E., Tezcan E.

PSYCHOLOGICAL MEDICINE, vol.37, no.1, pp.121-129, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1017/s0033291706008968
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.121-129
  • Bezmialem Vakıf University Affiliated: Yes


Background. No study to date has examined the effects of mood stabilizer alone and the combination of mood stabilizer and atypical antipsychotic, quetiapine, on hippocampal neurochemical markers of bipolar disordered patients con currently. We therefore undertook a proton magnetic resonance spectroscopy ((1)H MRS) study of drug-free patients with bipolar disorder (drug-free group), patients undergoing valproate treatment (valproate group), patients administered valproate+quetiapine (valprote+quetiapine group) and healthy controls, focusing on the in vivo neuroanatomy of the hippocampus.