Hippocampal (1)H MRS in patients with bipolar disorder taking valproate versus valproate plus quetiapine

Atmaca M., Yildirim H., Ozdemir H. , Ogur E., Tezcan E.

PSYCHOLOGICAL MEDICINE, cilt.37, sa.1, ss.121-129, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Konu: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1017/s0033291706008968
  • Sayfa Sayıları: ss.121-129


Background. No study to date has examined the effects of mood stabilizer alone and the combination of mood stabilizer and atypical antipsychotic, quetiapine, on hippocampal neurochemical markers of bipolar disordered patients con currently. We therefore undertook a proton magnetic resonance spectroscopy ((1)H MRS) study of drug-free patients with bipolar disorder (drug-free group), patients undergoing valproate treatment (valproate group), patients administered valproate+quetiapine (valprote+quetiapine group) and healthy controls, focusing on the in vivo neuroanatomy of the hippocampus.