Modulating the cellular uptake of platinum drugs with glycopolymers


Dag A. , CALLARI M., Lu H., STENZEL M. H.

POLYMER CHEMISTRY, cilt.7, ss.1031-1036, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 7 Konu: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1039/c5py01579k
  • Dergi Adı: POLYMER CHEMISTRY
  • Sayfa Sayıları: ss.1031-1036

Özet

The therapeutic potency of platinum-based anticancer drugs can be substantially improved through the use of polymeric nano-carrier systems to target cancer cells efficiently. We synthesized a series of glyco-block copolymers with three different sugars able to self-assemble into nanoparticles when conjugated with 1,2-diamino-cyclopentane platinum(II) (DACP-Pt). The polymers are based on (2-(D-glucosyloxy) ethyl methacrylate (glucose; GlcMA), 2-(D-galactosyloxy) ethyl methacrylate (galactose; GalMA), 1-O-methacryloyl-beta-D-fructopyranose (fructose; FrucMA1), and 3-Omethacryloyl-beta-D-fructopyranose (fructose; FrucMA3)). They are all readily taken up intracellularly by the breast cancer cell lines MCF-7 and MDA-MB-231 and the ovarian cancer cell line A2780. All cell lines expressed a high preference for the fructose coated nanoparticles. The nanocarriers were themselves nontoxic, but exhibited high cytotoxicity and increased efficacy when conjugated with the DACP-Pt drug.