Alpha-Melanocyte-Stimulating Hormone and Agouti-Related Protein: Do They Play a Role in Appetite Regulation in Childhood Obesity?


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Vehapoglu A. , TURKMEN S., Terzioglu S.

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.8, ss.40-47, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 8 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4274/jcrpe.2136
  • Dergi Adı: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
  • Sayfa Sayısı: ss.40-47

Özet

Objective: The hypothalamus plays a crucial role in the regulation of feeding behavior. The anorexigenic neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) and the orexigenic neuropeptide agouti-related protein (AgRP) are among the major peptides produced in the hypothalamus. This study investigated the plasma concentrations of alpha-MSH and AgRP in underweight and obese children and their healthy peers. The associations between alpha-MSH and AgRP levels and anthropometric and nutritional markers of malnutrition and obesity were also assessed.