JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, vol.8, no.1, pp.40-47, 2016 (Journal Indexed in SCI)
Article / Article
Title of Journal :
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
Alpha-melanocyte-stimulating hormone, agouti-related protein, underweight, childhood obesity, PROOPIOMELANOCORTIN POMC NEURONS, BODY-MASS-INDEX, MELANOCORTIN-4 RECEPTOR, PLASMA-CONCENTRATIONS, ANOREXIA-NERVOSA, LEPTIN, ASSOCIATION, SYSTEM, NEUROPEPTIDES, GLUCOSE
Objective: The hypothalamus plays a crucial role in the regulation of feeding behavior. The anorexigenic neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) and the orexigenic neuropeptide agouti-related protein (AgRP) are among the major peptides produced in the hypothalamus. This study investigated the plasma concentrations of alpha-MSH and AgRP in underweight and obese children and their healthy peers. The associations between alpha-MSH and AgRP levels and anthropometric and nutritional markers of malnutrition and obesity were also assessed.