Alpha-Melanocyte-Stimulating Hormone and Agouti-Related Protein: Do They Play a Role in Appetite Regulation in Childhood Obesity?


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Vehapoglu A. , TURKMEN S., Terzioglu S.

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, vol.8, no.1, pp.40-47, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.4274/jcrpe.2136
  • Title of Journal : JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
  • Page Numbers: pp.40-47
  • Keywords: Alpha-melanocyte-stimulating hormone, agouti-related protein, underweight, childhood obesity, PROOPIOMELANOCORTIN POMC NEURONS, BODY-MASS-INDEX, MELANOCORTIN-4 RECEPTOR, PLASMA-CONCENTRATIONS, ANOREXIA-NERVOSA, LEPTIN, ASSOCIATION, SYSTEM, NEUROPEPTIDES, GLUCOSE

Abstract

Objective: The hypothalamus plays a crucial role in the regulation of feeding behavior. The anorexigenic neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) and the orexigenic neuropeptide agouti-related protein (AgRP) are among the major peptides produced in the hypothalamus. This study investigated the plasma concentrations of alpha-MSH and AgRP in underweight and obese children and their healthy peers. The associations between alpha-MSH and AgRP levels and anthropometric and nutritional markers of malnutrition and obesity were also assessed.