8-Hydroxydeoxyguanosine: A Valuable Predictor of Oxidative DNA Damage in Cancer and Diabetes Mellitus

İzzettin F. V., Sancar M.

in: Cancer Oxidative Stress and Dietary Antioxidants, Victor Preedy,Vinood Patel, Editor, Elsevier Science, Oxford/Amsterdam , Amsterdam, pp.1-596, 2021

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2021
  • Publisher: Elsevier Science, Oxford/Amsterdam 
  • City: Amsterdam
  • Page Numbers: pp.1-596
  • Editors: Victor Preedy,Vinood Patel, Editor
  • Bezmialem Vakıf University Affiliated: Yes


Oxidative stress is a consequence attack of cellular macromolecules caused by reactive oxygen species during normal and pathophysiological processes in the living cells. It results in oxidative nuclear and mitochondrial DNA damage which is implicated in the pathogenesis of a wide variety of diseases. During oxidative stress in mammalian cells, one of the most potentially oxidized mutagenic DNA lesions formed upon DNA repair is 8-hydroxydeoxyguanosine (8-OHdG), a frequently detected nucleoside repair product. Numerous evidences reported significant elevated levels of 8-OHdG in many conditions, including cancer, diabetes mellitus and cancer radio-chemotherapy. Moreover, its level is positively correlated with the severity of diabetic micro- and macro-vascular complications suggesting 8-OHdG as a novel and pivotal biomarker in the assessment of various conditions related to generalized, cellular oxidative stress and oxidative DNA damage.