The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non-ST-elevation acute coronary syndrome

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Sonmez E., TURKDOGAN K. A., KARABACAK M., CİVELEK C., YILMAZ C., Ozer O. F., ...More

AMERICAN JOURNAL OF EMERGENCY MEDICINE, vol.33, no.1, pp.21-24, 2015 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 33 Issue: 1
• Publication Date: 2015
• Doi Number: 10.1016/j.ajem.2014.09.047
• Journal Name: AMERICAN JOURNAL OF EMERGENCY MEDICINE
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.21-24
• Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: Chest pain and/or electrocardiogram changes in non-ST elevation or suspicious chest pain and cardiac marker elevations are defined as non-ST-elevation acute coronary syndrome (NSTE-ACS). Serial electrocardiogram and marker follow-up are needed to make a diagnosis of NSTE-ACS and to eliminate noncoronary chest pain (NCCP). Signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) is stored within the a granules of inactive platelets and secreted at a high rate during thrombosis. We believe that SCUBE1 may be a sensitive early diagnostic indicator in distinguishing coronary-induced chest pain from noncoronary-induced chest pain.