The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non-ST-elevation acute coronary syndrome


Sonmez E. , TURKDOGAN K. A. , KARABACAK M., CİVELEK C., YILMAZ C., Ozer O. F. , et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE, cilt.33, ss.21-24, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 33 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.ajem.2014.09.047
  • Dergi Adı: AMERICAN JOURNAL OF EMERGENCY MEDICINE
  • Sayfa Sayısı: ss.21-24

Özet

Objective: Chest pain and/or electrocardiogram changes in non-ST elevation or suspicious chest pain and cardiac marker elevations are defined as non-ST-elevation acute coronary syndrome (NSTE-ACS). Serial electrocardiogram and marker follow-up are needed to make a diagnosis of NSTE-ACS and to eliminate noncoronary chest pain (NCCP). Signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) is stored within the a granules of inactive platelets and secreted at a high rate during thrombosis. We believe that SCUBE1 may be a sensitive early diagnostic indicator in distinguishing coronary-induced chest pain from noncoronary-induced chest pain.