Preparation and Evaluation of Inflammation Targeted Nano-micellar Formulation of Celecoxib

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BAHADORİ F., Buyuk A. S., KOZANOĞLU A. S., Eskandari Z., ANKARALI H., Kepekci Tekkeli S. E., ...More

BEZMIALEM SCIENCE, vol.7, no.3, pp.208-214, 2019 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.14235/bas.galenos.2018.2673
  • Journal Name: BEZMIALEM SCIENCE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.208-214
  • Keywords: Targeted inflammation therapy, Celecoxib, nano drug delivery system, PLGA, COX2, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, BIODEGRADABLE POLYMERS, RHEUMATOID-ARTHRITIS, HPLC METHOD, NANOPARTICLES, POLYLACTIDE, COX-1, RISK
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: Celecoxib (CLX), brand named Celebrex, which belongs to non-steroidal anti-inflammatory drugs family, selectively inhibits the cytokine related cyclooxygenase-2 isoenzyme and thus, possesses less gastrointestinal side effects, have shown to cause stroke, myocard infarction and even death in some cases. In this study we aimed to target inflammation site using CLX uploaded nano-micelles (nano-CLX) made of poly (lactic-co-glycolic) acid (PLGA) to protect other tissues from its side effects.