Beyond anti-microbial properties: The role of cathelicidin in allergic rhinitis.

DILEK F., Gultepe B., OZKAYA E., YAZICI M., GEDIK A. H., CAKIR E.

Allergologia et immunopathologia, vol.44, no.4, pp.297-302, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1016/j.aller.2015.07.006
  • Journal Name: Allergologia et immunopathologia
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.297-302
  • Keywords: Allergic rhinitis, Nasal fluid, Disease severity, Cathelicidin, LL-37, PEPTIDE LL-37, LAVAGE FLUID, EXPRESSION, DEFENSINS, HEALTHY, INNATE, ASTHMA
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Cathelicidin, an anti-microbial peptide, is a component of the innate immune system. Cathelicidin has anti-microbial, anti-inflammatory and immunoregulatory functions. Knowledge about the role of the innate immune system in the pathogenesis of allergic diseases has expanded in recent years. We measured levels of the LL-37 peptide in the nasal fluids of children with allergic rhinitis (AR) and investigated the possible role of this peptide in the pathogenesis of AR.