The role of midkine in the inflammatory process and its correlation with other inflammatory markers in renal transplant recipients.


Uzun S., Kaya B., Celik K., Behlul A., Ozkan O., Kuvvet M., ...More

The International journal of artificial organs, vol.39, no.6, pp.277-81, 2016 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.5301/ijao.5000510
  • Title of Journal : The International journal of artificial organs
  • Page Numbers: pp.277-81

Abstract

Background: Midkine (MK), which is expressed in the proximal tubular epithelial cells of the kidney, is thought to have a role in the pathophysiology of inflammation-related renal diseases. Both immunological and nonimmunological mechanisms may affect renal functions negatively during the early and late post-transplantation periods. We aimed in our study to evaluate the relationship of MK with clinical findings and inflammatory markers, including high sensitivity C-reactive protein (hs-CRP), interleukin (IL-6) and tumor necrosis factor (TNF-alpha) in the pretransplant and post-transplant period.