The 58th Annual ESPE Meeting, Vienna, Austria, 19 - 21 September 2019, no.396, pp.326
Background and Aims: Irisin is a newly discovered adipomyokine that occurs by the cleaved from a transmembrane protein called “Fibronectintype III domain containing 5” (FNDC5).
Previously, there was a change in irisin levels in different prepubertal and pubertal stages.Although the mechanisms that trigger
the onset of puberty cannot be explained yet, there is a hypothesis
that peripheral adipose tissue and adipokines secreted there may
induce the initiation of puberty by stimulating the central neural
network.The aim of our study was to compare the levels of irisin
in prepubertal and prepubertal children and to determine whether
adipomyokine could be used as a marker.
Methods: The study was perfomed in 94 girls, with 33 precocious puberty, 31 premature thelarche and 30 prepubertal volunteers.Age and body mass index (BMI) standard deviation score
(SDS) groups were generated.The levels of irisin were compared
between groups. Also examined the correlations between irisin
and age, BMI-SDS, height-SDS, weight-SDS, bone age, uterine
axis, right ovary size, left ovary size, basal FSH, basal LH, peak
FSH, peak LH and estradiol (E2). With multiple regression analysis the most important factors that influence the level of the irisin
have been identified.
Results: The table comparing the precocious puberty, premature
thelarche and control group is as follows (Table 1).There was a
positive correlation between irisin and BMI-SDS, height-SDS,
weight-SDS, bone age, uterine axis, right ovary size, left ovary
size, basal FSH, basal LH, peak FSH and peak LH. In the multiple
regression analysis, it was observed that the most important factor
associated with irisin was the peak LH level, respectively, and age
and BMI-SDS respectively.
Conclusions: The irisin levels were significantly higher in
the precocious puberty group than the premature thelarche and
the control group.Although there is a finding supporting the
hypothesis that the elevation of irisin may be effective on the onset
of puberty, it is not possible to confirm this hypothesis with this
study.It can also be thought that increased muscle and fat tissue
during puberty may play a role in increasing irisin levels.In spite
of this, it was concluded that this increase in iris levels could be
useful in the diagnosis of precocious puberty and could be used as
a marker after higher number of patients studies.