Spectrofluorimetric Method for the Determination of Tolterodine In Human Plasma and Pharmaceutical Preparations by Derivatization with Dansyl Chloride

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TEKKELİ Ş. E.

BEZMIALEM SCIENCE, vol.5, no.2, pp.50-55, 2017 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.14235/bs.2016.500
  • Journal Name: BEZMIALEM SCIENCE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.50-55
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: Tolterodine (TOL) is an anti-muscarinic drug used for the symptomatic treatment of urinary incontinence. Analytical methods in the literature are not sensitive enough for the assay of drug substance biological fluids. To make up the deficit, we developed a sensitive, cost-reduced spectrofluorimetric method for the determination of TOL in plasma and pharmaceutical preparations.