Origami with ABC Triblock Terpolymers Based on Glycopolymers: Creation of Virus-Like Morphologies


Creative Commons License

Dag A. , ZHAO J., STENZEL M. H.

ACS MACRO LETTERS, vol.4, no.5, pp.579-583, 2015 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.1021/acsmacrolett.5b00163
  • Title of Journal : ACS MACRO LETTERS
  • Page Numbers: pp.579-583

Abstract

Morphologies, that resemble viruses, were created using a single ABC triblock terpolymer poly(2-acryloylethyl-alpha-D-mannopyranoside)-b-poly(n-butyl acrylate)-b-poly(4-vinylpyridine) (PAcManA(70)-b-PBA(369)-b-PVP370). Morphologies ranging from flower-like micelles, cylindrical micelles, raspberry-like morphologies to nanocaterpillars were obtained by adjusting the pH value during the self-assembly process. The resulting nanoparticles had an abundance of mannose on the surface, which were recognized by the mannose receptors of RAW264.7, a macrophage cell line that can be used as a model for virus entry.