Origami with ABC Triblock Terpolymers Based on Glycopolymers: Creation of Virus-Like Morphologies


Dag A. , ZHAO J., STENZEL M. H.

ACS MACRO LETTERS, cilt.4, ss.579-583, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 4 Konu: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1021/acsmacrolett.5b00163
  • Dergi Adı: ACS MACRO LETTERS
  • Sayfa Sayısı: ss.579-583

Özet

Morphologies, that resemble viruses, were created using a single ABC triblock terpolymer poly(2-acryloylethyl-alpha-D-mannopyranoside)-b-poly(n-butyl acrylate)-b-poly(4-vinylpyridine) (PAcManA(70)-b-PBA(369)-b-PVP370). Morphologies ranging from flower-like micelles, cylindrical micelles, raspberry-like morphologies to nanocaterpillars were obtained by adjusting the pH value during the self-assembly process. The resulting nanoparticles had an abundance of mannose on the surface, which were recognized by the mannose receptors of RAW264.7, a macrophage cell line that can be used as a model for virus entry.