Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line


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Tuncay S., Senol H. , Guler E. M. , Ocal N., Seçen H., Kocyigit A. , ...Daha Fazla

MEDICINAL CHEMISTRY, cilt.14, ss.617-625, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by H-1- and C-13 NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner.