Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line

Creative Commons License

Tuncay S., Senol H., Guler E. M., Ocal N., Seçen H., Kocyigit A., ...More

MEDICINAL CHEMISTRY, vol.14, pp.617-625, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2018
  • Doi Number: 10.2174/1573406414666180222094544
  • Journal Name: MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.617-625
  • Keywords: Triterpenoids, Oleanolic acid, Spectral analysis, Cytotoxicity, Erythrodiol, CANCER CELLS, IN-VITRO, DERIVATIVES, TRITERPENOIDS, INHIBITION, AGENTS, VIVO
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by H-1- and C-13 NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner.