Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line

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Tuncay S., Senol H. , Guler E. M. , Ocal N., Seçen H., Kocyigit A. , ...More

MEDICINAL CHEMISTRY, vol.14, pp.617-625, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2018
  • Doi Number: 10.2174/1573406414666180222094544
  • Title of Journal : MEDICINAL CHEMISTRY
  • Page Numbers: pp.617-625


Background: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by H-1- and C-13 NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner.