The effect of isradipine on maximal electroshock seizures in mice

Ozyazgan S., Senses V., Utkan T., Yildiran G., ULAK G., Gacar N., ...More

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, vol.31, no.1, pp.133-135, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 1
  • Publication Date: 1998
  • Doi Number: 10.1016/s0306-3623(97)00390-x
  • Journal Name: GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.133-135
  • Keywords: isradipine, maximal electroshock seizure, mice, CALCIUM ENTRY BLOCKERS, EXCITATORY AMINO-ACIDS, ADD-ON THERAPY, SPINAL-CORD, RAT-BRAIN, RECEPTORS, EPILEPSY, CHANNELS, NEURONS, SYSTEM
  • Bezmialem Vakıf University Affiliated: No

Abstract

1. The aim of this study was to investigate the possible anticonvulsant effect of a dihydropyridine calcium antagonist, isradipine, which easily crosses the blood-brain barrier displaying high affinity and specificity for the brain L-type voltage-sensitive calcium channel, on maximal electroshock seizures in mice.