N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats

Cetinkaya A., Bulbuloglu E., Kurutas E. B., Kantarceken B.

MEDICAL SCIENCE MONITOR, cilt.12, sa.8, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 8
  • Basım Tarihi: 2006
  • Dergi Adı: MEDICAL SCIENCE MONITOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: methotrexate, N-acetylcysteine, liver damage, INHIBITS LEUKOCYTE DEATH, RHEUMATOID-ARTHRITIS, FOLIC-ACID, INDUCED TOXICITY, FREE-RADICALS, DOUBLE-BLIND, DNA-DAMAGE, IN-VITRO, STRESS, INJURY
  • Bezmiâlem Vakıf Üniversitesi Adresli: Hayır

Özet

Background: Methotrexate (MTX), a folic acid antagonist, is widely used as a cytotoxic chemotherapeutic agent for malignancies as well as in the treatment of various inflammatory diseases. The efficacy of this agent is often limited by severe side effects and toxic conditions. The present study was undertaken to determine whether N-acetylcysteine (NAC), as a potent antioxidant Compound, could ameliorate MTX-induced oxidative liver damage.