N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats


Cetinkaya A., Bulbuloglu E. , Kurutas E. B. , Kantarceken B.

MEDICAL SCIENCE MONITOR, vol.12, no.8, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 8
  • Publication Date: 2006
  • Title of Journal : MEDICAL SCIENCE MONITOR
  • Keywords: methotrexate, N-acetylcysteine, liver damage, INHIBITS LEUKOCYTE DEATH, RHEUMATOID-ARTHRITIS, FOLIC-ACID, INDUCED TOXICITY, FREE-RADICALS, DOUBLE-BLIND, DNA-DAMAGE, IN-VITRO, STRESS, INJURY

Abstract

Background: Methotrexate (MTX), a folic acid antagonist, is widely used as a cytotoxic chemotherapeutic agent for malignancies as well as in the treatment of various inflammatory diseases. The efficacy of this agent is often limited by severe side effects and toxic conditions. The present study was undertaken to determine whether N-acetylcysteine (NAC), as a potent antioxidant Compound, could ameliorate MTX-induced oxidative liver damage.