N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats

Cetinkaya A., Bulbuloglu E., Kurutas E. B., Kantarceken B.

MEDICAL SCIENCE MONITOR, vol.12, no.8, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 8
  • Publication Date: 2006
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: methotrexate, N-acetylcysteine, liver damage, INHIBITS LEUKOCYTE DEATH, RHEUMATOID-ARTHRITIS, FOLIC-ACID, INDUCED TOXICITY, FREE-RADICALS, DOUBLE-BLIND, DNA-DAMAGE, IN-VITRO, STRESS, INJURY
  • Bezmialem Vakıf University Affiliated: No

Abstract

Background: Methotrexate (MTX), a folic acid antagonist, is widely used as a cytotoxic chemotherapeutic agent for malignancies as well as in the treatment of various inflammatory diseases. The efficacy of this agent is often limited by severe side effects and toxic conditions. The present study was undertaken to determine whether N-acetylcysteine (NAC), as a potent antioxidant Compound, could ameliorate MTX-induced oxidative liver damage.