Impact of Copper and Oxidative Stress Index Levels on Insulin Resistance, Lipid Profile and Hormonal Status of Patients with Polycystic Ovary Syndrome

ATAKUL N., SELEK Ş., KÖKTAŞOĞLU F., KILIÇ B. Ş., GÜL A. Z., ATAMER Y.

ISTANBUL MEDICAL JOURNAL, vol.23, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23
  • Publication Date: 2022
  • Doi Number: 10.4274/imj.galenos.2022.28445
  • Journal Name: ISTANBUL MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Keywords: Polycystic ovary syndrome, copper, oxidative stress, testosterone, SYNDROME PCOS, WOMEN, MARKERS, PARAMETERS, PHENOTYPES, CAPACITY, METALS
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine abnormalities of reproductive age and has a highly heterogeneous nature regarding its multisystemic symptoms. To elicit pathophysiological roots, metabolic mapping and between-correlations among key parameters are of vital importance. We generated a platform including cardinal hormones, lipids, homeostasis model assessment of insulin resistance (HOMA-IR) and oxidative markers [total-oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), copper (Cu)] related to pathophysiology.