Association of CDH1 -160 C -> A and -347 G -> GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study

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AKÇAKAYA A., Unver N., Kiris T. A., Guzel M., AKÇAKAYA F. B., ÇAKMAKOĞLU B., ...More

TURKISH JOURNAL OF SURGERY, vol.37, no.1, pp.41-48, 2021 (ESCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.47717/turkjsurg.2021.5097
  • Journal Name: TURKISH JOURNAL OF SURGERY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.41-48
  • Keywords: CDH1 polymorphisms, E-cadherin, gastric carcinoma, immunohistochemical expression, survival, C-160A PROMOTER POLYMORPHISM, GERMLINE MUTATIONS, GENE, RISK, PATTERN
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: The loss of function of the E-cadherin (CDH1) gene with -160 C -> A and -347 G -> GA polymorphisms is regarded as a critical step for gastric cancer. It was aimed to investigate possible association of these polymorphisms and immunoexpression of E-cadherin with gastric cancer.