Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model

Elibol, BİRSEN; Beker, MERVE; Terzioglu-Usak, ŞULE; Dalli, Tugce; Kilic, Ulkan

doi:10.1016/j.phymed.2020.153324

Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model

Elibol B., Beker M., Terzioglu-Usak S., Dalli T., Kilic U.

PHYTOMEDICINE, cilt.79, 2020 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 79
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.phymed.2020.153324
Dergi Adı: PHYTOMEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
Anahtar Kelimeler: Alzheimer's disease, Amyloid beta((1-42)), Hippocampus, Rat, Thymoquinone, OXIDATIVE STRESS, NIGELLA-SATIVA, MEMORY IMPAIRMENT, MOUSE MODEL, BETA, EXPRESSION, PHOSPHORYLATION, INHIBITION, EXTRACT, SEX
Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Background: Thymoquinone (TQ), a biologically active ingredient of Nigella sativa, has anti-inflammatory, antioxidative and neuroprotective properties. Therefore, it could be a good candidate in the recovery of Alzheimer's disease (AD) pathology rather than current symptomatic reliefs.