Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model

Elibol, BİRSEN; Beker, MERVE; Terzioglu-Usak, ŞULE; Dalli, Tugce; Kilic, Ulkan

doi:10.1016/j.phymed.2020.153324

Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model

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Elibol B., Beker M., Terzioglu-Usak S., Dalli T., Kilic U.

PHYTOMEDICINE, vol.79, 2020 (SCI-Expanded)

Publication Type: Article / Article
Volume: 79
Publication Date: 2020
Doi Number: 10.1016/j.phymed.2020.153324
Journal Name: PHYTOMEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
Keywords: Alzheimer's disease, Amyloid beta((1-42)), Hippocampus, Rat, Thymoquinone, OXIDATIVE STRESS, NIGELLA-SATIVA, MEMORY IMPAIRMENT, MOUSE MODEL, BETA, EXPRESSION, PHOSPHORYLATION, INHIBITION, EXTRACT, SEX
Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Thymoquinone (TQ), a biologically active ingredient of Nigella sativa, has anti-inflammatory, antioxidative and neuroprotective properties. Therefore, it could be a good candidate in the recovery of Alzheimer's disease (AD) pathology rather than current symptomatic reliefs.