An Investigation into the Relationship of Sur1-Trpm4 Receptor with Peritumoral Edema in High-Grade Glial Tumors

Dundar T. T., Seyithanoglu M. H., Coban G., Yurtsever İ., Toprak A., Oztanir M. N.

TURKISH NEUROSURGERY, cilt.34, sa.1, ss.93-101, 2024 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.5137/1019-5149.jtn.36251-21.4
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
  • Sayfa Sayıları: ss.93-101
  • Anahtar Kelimeler: Brain tumor, Cerebral edema, Glial tumor, Glioblastoma, Sur1-Trpm4
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

AIM: To investigate the presence of Sur1-Trpm4 receptors in high-grade glial tumors, and their relationship with edema volumes in preoperative magnetic resonance imaging (MRI) sequences. MATERIAL and METHODS: MRI sections were extracted from T1-weighted (T1W) and T2-weighted (T2W) sequences and fluid attenuated inversion recovery (FLAIR) images. After that, T1W 3D magnetization-prepared rapid gradient echo (MP-RAGE) sequences were taken with and without contrast medium. Tumor and peritumoral edema volumes were calculated in cubic centimeters. Sur1Trpm4 receptors were studied by immunohistochemical examination of tissue samples. Relationships between data were analyzed using Spearman's correlation coefficient. RESULTS: In the immunohistochemical examinations, 58% of the samples from patients with high-grade glial tumors were positive for Sur1 and 74% were positive for Trpm4. The volume of tumors was correlated with the volume of peritumoral edema. CONCLUSION: The presence of the Sur1-Trpm4 receptor complex in high-grade glial tumors was confirmed. Further preclinical or clinical studies are required to identify and validate the role of Sur1-Trpm4 in glial tumor subgroups.