Resveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity

Velioglu-Ogunc A., Sehirli O., Toklu H. Z., Ozyurt H., Mayadagli A., Eksioglu-Demiralp E., ...More

FREE RADICAL RESEARCH, vol.43, no.11, pp.1060-1071, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 11
  • Publication Date: 2009
  • Doi Number: 10.1080/10715760903171100
  • Journal Name: FREE RADICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1060-1071
  • Keywords: Irradiation, lipid peroxidation, glutathione, myeloperoxidase, resveratrol, INDUCED OXIDATIVE STRESS, INDUCED LUNG INJURY, IONIZING-RADIATION, RED WINE, RATS, MECHANISM, CANCER, CELLS, ORGAN, ACID
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

The present study was undertaken to determine whether resveratrol (RVT) could ameliorate ionizing radiation-induced oxidative injury. After a 10-days pre-treatment with RVT (10 mg/kg/day p.o.), rats were exposed to whole-body IR (800 cGy) and the RVT treatment was continued for 10 more days after the irradiation. Irradiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and collagen content were increased in the liver and ileum tissues. Similarly, plasma lactate dehydrogenase and pro-inflammatory cytokine levels, 8-hydroxy-2'-deoxyguanosine and leukocyte apoptosis were elevated, while antioxidant-capacity was reduced in the irradiated rats as compared with the control group. Furthermore, Na-1, K-1 -ATPase activity was inhibited and DNA fragmentation was increased in the ileal tissues. Resveratrol treatment reversed all these biochemical indices, as well as histopathological alterations induced by irradiation. In conclusion, supplementing cancer patients with adjuvant therapy of resveratrol may have some benefit for a more successful radiotherapy.