Mapping HLA-A2,-A3 and-B7 supertype-restricted T-cell epitopes in the ebolavirus proteome


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Lim W. C. , Khan A. M.

BMC GENOMICS, vol.19, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19
  • Publication Date: 2018
  • Doi Number: 10.1186/s12864-017-4328-8
  • Title of Journal : BMC GENOMICS
  • Keywords: Ebolavirus, T-cell epitope, HLA supertype, Antigenic diversity, HEMORRHAGIC-FEVER, VACCINE DEVELOPMENT, CTL EPITOPES, VIRUS, PREDICTION, IDENTIFICATION, DATABASE, TARGETS, POLYMORPHISM, INFECTION

Abstract

Background: Ebolavirus (EBOV) is responsible for one of the most fatal diseases encountered by mankind. Cellular T-cell responses have been implicated to be important in providing protection against the virus. Antigenic variation can result in viral escape from immune recognition. Mapping targets of immune responses among the sequence of viral proteins is, thus, an important first step towards understanding the immune responses to viral variants and can aid in the identification of vaccine targets. Herein, we performed a large-scale, proteome-wide mapping and diversity analyses of putative HLA supertype-restricted T-cell epitopes of Zaire ebolavirus (ZEBOV), the most pathogenic species among the EBOV family.