Increased DNA damage in patients with chronic obstructive pulmonary disease who had once smoked or been exposed to biomass

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CEYLAN E., Kocyigit A. , GENCER M. A. , AKSOY N., SELEK S.

RESPIRATORY MEDICINE, vol.100, no.7, pp.1270-1276, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 100 Issue: 7
  • Publication Date: 2006
  • Doi Number: 10.1016/j.rmed.2005.10.011
  • Title of Journal : RESPIRATORY MEDICINE
  • Page Numbers: pp.1270-1276
  • Keywords: chronic obstructive pulmonary disease, smoking, biomass exposure, DNA damage, CIGARETTE-SMOKE, OXIDATIVE STRESS, PLASMA, PREVENTION, METABOLISM, PROTEINS, OXIDANTS, PHASE, ASSAY


Objective: Chronic obstructive pulmonary disease (COPD) is a slowly progressive condition characterised by poorly reversible airflow limitation associated with an abnormal inflammatory response of the lung. The main causal factors of COPD are chronic oxidative stress as a result of long-term smoking, use of biomass fuels, and air pollution. In this study, basal levels of DNA strand breaks were investigated together with some additional oxidative markers implicating oxidative damage on the other biomolecules such as proteins and lipids in patients with COPD who were exposed to smoking and biomass.