Ovarian Granulosa Cell Tumor: A Clinicoradiologic Series with Litera- ture Review

Kilinc Y. B., Sari L., Toprak H., Gultekin M. A., Karabulut U. E., ŞAHİN N.

CURRENT MEDICAL IMAGING, vol.17, no.6, pp.790-797, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.2174/1573405616666201228153755
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.790-797
  • Keywords: Ovarian granulosa cell tumor, MRI, US, sex cord-stromal cells, juvenile granulosa cell tumors (JGCT), adult granu-losa cell tumors (AGCT), INITIAL DIAGNOSIS, METASTASIS, ADULT, CT
  • Bezmialem Vakıf University Affiliated: Yes


Background: Ovarian granulosa cell tumors that originate from the sex cord-stromal cells represent 2% to 5% of all ovarian cancers. These tumors constitute two subgroups according to their clinical and histopathological features: juvenile granulosa cell tumors (JGCT) and adult granulosa cell tumors (AGCT). Granulosa cell tumor (GCT) is considered to be a low-grade malignancy with a favorable prognosis. Methods: This case series includes four patients who were admitted to our university hospital and had an MRI examination within 5 years. Results: The histopathological subtype of granulosa tumor was the adult type in 3 patients and juvenile type in 1 patient. Even though it is extremely rare, bone metastases were present in one of our patients. Liver metastases were also detected in one patient. The MRI examination of tumors revealed a heterogeneous solid mass that contained cystic components in 3 patients. In one of our patients, the tumor had a multiseptated cystic feature, and all of the tumors were ovoid or round with smooth margins. T1 signal hyperintensity, not suppressed on fat saturation sequences, was observed in 3 patients, which represents its hemorrhagic content. Conclusion: Even though granulosa cell tumor shows a wide spectrum in terms of tumor appearance, some common findings have been shown and especially a hemorrhagic content could be a clue for us. The tumor is known to have a good prognosis, but it may have an unpredictable clinical course, so close follow-up is greatly important.