Anticholinergic and antioxidant activities of avocado (Folium perseae) leaves - phytochemical content by LC-MS/MS analysis


Kose L. P. , Bingol Z., Kaya R., GÖREN A. C. , Akincioglu H., DURMAZ L., ...More

INTERNATIONAL JOURNAL OF FOOD PROPERTIES, vol.23, no.1, pp.878-893, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.1080/10942912.2020.1761829
  • Title of Journal : INTERNATIONAL JOURNAL OF FOOD PROPERTIES
  • Page Numbers: pp.878-893
  • Keywords: Avocado, Folium perseae, antioxidant activity, radical scavenging, acetylcholinesterase, butyrylcholinesterase, IN-VITRO ANTIOXIDANT, RADICAL SCAVENGING ACTIVITY, POTENT CARBONIC-ANHYDRASE, POLYPHENOL CONTENTS, ANTIRADICAL ACTIVITIES, INHIBITION PROFILES, 1ST SYNTHESIS, ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, BROMOPHENOLS

Abstract

In the first stage of the manuscript, we aimed to examine antioxidant capacity and anticholinergic properties of avocado (Folium perseae) leaves. Avocado leaf was extracted by water (WEFP) and ethyl alcohol (EEFP) and antioxidant activity was determined using by several antioxidant assays including DPPHGreek ano teleia and ABTS(center dot+)radical scavenging assays, Cu2+-Cu(+)reducing, Fe3+-Fe(2+)reducing, and FRAP reducing activities. Avocado leaf extracts demonstrated antioxidant activity and anticholinergic activities, while alpha-tocopherol, BHT, trolox, and BHA were used as positive antioxidant controls. In the second part of this study, the inhibition effects of WEFP and EEFP were valuated against acetylcholinesterase and butyrylcholinesterase enzymes, which catalyze the breakdown of choline esters (i.e. neurotransmitters). This study obviously showed that avocado leaf extracts had effective antioxidant, antiradical, and anticholinergic influences.