Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids


Ozcelik B., Kartal M. , Orhan I.

PHARMACEUTICAL BIOLOGY, vol.49, no.4, pp.396-402, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.3109/13880209.2010.519390
  • Title of Journal : PHARMACEUTICAL BIOLOGY
  • Page Numbers: pp.396-402

Abstract

Materials and methods: Antiviral activity of the compounds was tested against DNA virus herpes simplex type 1 and RNA virus parainfluenza (type-3). Cytotoxicity of the compounds was determined using Madin-Darby bovine kidney and Vero cell lines, and their cytopathogenic effects were expressed as maximum non-toxic concentration. Antibacterial activity was assayed against following bacteria and their isolated strains: Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis, although they were screened by microdilution method against two fungi: Candida albicans and Candida parapsilosis.