Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids


Ozcelik B., Kartal M. , Orhan I.

PHARMACEUTICAL BIOLOGY, cilt.49, ss.396-402, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 49 Konu: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/13880209.2010.519390
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Sayfa Sayısı: ss.396-402

Özet

Materials and methods: Antiviral activity of the compounds was tested against DNA virus herpes simplex type 1 and RNA virus parainfluenza (type-3). Cytotoxicity of the compounds was determined using Madin-Darby bovine kidney and Vero cell lines, and their cytopathogenic effects were expressed as maximum non-toxic concentration. Antibacterial activity was assayed against following bacteria and their isolated strains: Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis, although they were screened by microdilution method against two fungi: Candida albicans and Candida parapsilosis.