Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids

Ozcelik B., Kartal M., Orhan I.

PHARMACEUTICAL BIOLOGY, vol.49, no.4, pp.396-402, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.3109/13880209.2010.519390
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.396-402
  • Keywords: Alkaloids, antimicrobial activity, antiviral activity, flavonoids, herpes simplex, parainfluenza, phenolic acids, HERPES-SIMPLEX VIRUSES, MEDICINAL-PLANTS, IN-VITRO, EXTRACTS, SILYMARIN, TYPE-1, ANTIBACTERIAL, ISOQUINOLINE, ANTIFUNGAL, HEPATITIS
  • Bezmialem Vakıf University Affiliated: No


Materials and methods: Antiviral activity of the compounds was tested against DNA virus herpes simplex type 1 and RNA virus parainfluenza (type-3). Cytotoxicity of the compounds was determined using Madin-Darby bovine kidney and Vero cell lines, and their cytopathogenic effects were expressed as maximum non-toxic concentration. Antibacterial activity was assayed against following bacteria and their isolated strains: Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis, although they were screened by microdilution method against two fungi: Candida albicans and Candida parapsilosis.