Akademik Veri Yönetim Sistemi
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, cilt.14, sa.2, ss.101-105, 2023 (ESCI)
Aim: Accelerating the diagnosis of sepsis patients and the ability to determine the severity of sepsis will speed up the treatment and thus decrease mortality and morbidity. Hepcidin is the regulator of iron metabolism, also an antimicrobial peptide and acute phase reactant, which is synthesized in hepatocytes. In the study, we aimed to determine the diagnostic value of this peptide, which is effective in sepsis by contributing to host defense, in patients with sepsis and septic shock. Material and Methods: The study was carried out with patients who were admitted to the emergency department and were diagnosed with sepsis and healthy volunteers. Patients with a SOFA score of 2 and above were included in the study. The patient group was divided into sepsis and septic shock subgroups. Hepcidin, CRP, IL-6, TNF alpha, and leukocyte values were noted in the patient and control groups; also, SOFA scores were recorded. ROC analysis and AUC values were calculated for the determined data. P <0.05 value was considered statistically significant. Results: A total of 86 cases were included in the study, as a healthy control group (n=23) and patient group [sepsis (n=32) and septic shock (n=31)]. When the relationship between biomarkers and binary study groups was evaluated, a statistically significant difference was observed between the control group and the patient group for hepcidin, leukocyte, TNF alpha, IL-6 and CRP values (p<0,05). While leukocyte, TNF-alpha, IL-6 and CRP values were significant in the binary comparison of control-sepsis groups, hepcidin values were not significant. However, no significance was found in other biomarkers in the comparison of sepsisseptic shock, while there was a statistically significant difference in hepcidin values (p=0,043). While sensitivity, specificity, PPV and NPV were calculated for hepcidin as 96,7%; 37,5%; 60% and 92,31% respectively. Discussion: The ability to determine the severity of the disease in the pre-intensive care period will speed up the treatment significantly and help to reduce mortality. According to the obtained findings in our study, we believe that hepcidin may be a useful biomarker in the diagnosis of septic shock and is correlated to the severity of the disease.