Research Information System
10th EURAPS Research Council Meeting, Naples, Italy, 25 - 26 May 2022, pp.73
Introduction:
The surgical flap delaying has been shown to be effective in preventing partial flap loss or in
preparing larger flaps. However, there is no gold standard flap delay method in the literature. In
this study, the authors aimed to compare 3 types of surgical delay methods to determine which
model would increase more flap survival. The authors also investigated the effect of delay
methods on circulating mononuclear leukocytes as a parameter of DNA damage.
Materials and Methods:
Twenty-four Sprague-Dawley male rats were divided into 4 groups. All subjects had a 10 × 3 cm
modified McFarlane flap. Surface area measurements, biopsies, and blood samples were taken
on the day of sacrification; 7th day for the control group and 14th day for delay groups.
Results:
Between incisional surgery delay groups, a significant difference was found in necrosis and
apoptosis in the bipedicled group, and only necrosis in the tripedicled group compared to the
control. In terms of DNA damage, it was found higher in all experimental groups than in the
control group.
Conclusions:
Both incisional surgical delay procedures’ results were meaningfully effective when only
incisions were made without the elevation of flaps. In conclusion, bipedicled incisional surgical
delay seems to be the most effective method in McFarlane experimental flap model whereas
two-staged surgeries may increase the risk of systemic toxicity