Novel metabolic marker Afamin: A predictive factor for Large-for-Gestational-Age (LGA) fetus estimation in pregnancies with gestational diabetes mellitus?


Atakul N., Atamer Y., Selek S., Kilic B. S. , Unal F.

JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, vol.50, no.10, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 10
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jogoh.2021.102201
  • Journal Name: JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: Afamin, Gestational diabetes mellitus (GDM), Large for gestational age (LGA), 75gr-Oral Glucose Tolerance Test (OGTT), MATERNAL SERUM, BIRTH-WEIGHT, PLACENTAL-LACTOGEN, OXIDATIVE STRESS, WOMEN, GLUCOSE, ASSOCIATION, INSULIN, GROWTH, ASSAY

Abstract

Objective: Gestational diabetes mellitus (GDM) affects both maternal and fetal/infant outcomes during and after pregnancy. The reason for the high incidence of large-for-gestational-age (LGA) infants in GDM patients despite close monitorization of glucose levels with early detection of the disease remains unclear to date. Our study aims to investigate the levels of the third-trimester novel marker afamin in GDM versus non-GDM pregnancies in terms of glycemic control status and their utility in the prediction of LGA fetuses.