Do Low Serum UCH-L1 and TDP-43 Levels Indicate Disturbed Ubiquitin-Proteosome System in Autism Spectrum Disorder?

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Cetin I., Tezdig I., TARAKCLOGLU M. C., Kadak M. T., Demirel O. F., Ozer O. F., ...More

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, vol.54, no.3, pp.267-271, 2017 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.5152/npa.2017.14873
  • Journal Name: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.267-271
  • Keywords: Autism, UCH-L1, TDP-43, ubiquitination, C-TERMINAL HYDROLASE-L1, TRAUMATIC BRAIN-INJURY, PROTEIN, MUTATIONS, MICE, L1, PLASTICITY, BEHAVIOR, MEMORY, UBE3A
  • Open Archive Collection: AVESIS Open Access Collection
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Introduction: The mechanism of ubiquitination-related abnormalities causing neural development problems is still unclear. We examined the association between autism and serum transactive response DNAbinding protein-43 (TDP-43) and ubiquitin c-terminal hydrolase-L1 (UCH-L1) levels, both of which are members of the ubiquitinproteosome system.