Optimization of piribedil mucoadhesive tablets for efficient therapy of Parkinson's disease: physical characterization and ex vivo drug permeation through buccal mucosa

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Celik B., Ozdemir S., Demirkoz A. B., Uner M.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol.43, no.11, pp.1836-1845, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 43 Issue: 11
• Publication Date: 2017
• Doi Number: 10.1080/03639045.2017.1349785
• Journal Name: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1836-1845
• Keywords: Buccal tablets, controlled release, direct compression, hydroxypropyl methyl cellulose, mucoadhesion, piribedil, IN-VITRO, CONTROLLED-RELEASE, MATRIX TABLETS, DELIVERY, FORMULATION, MECHANISMS, POLYMERS, DESIGN, TRANSPORT
• Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: The aim of this study was optimization of buccal piribedil (PR) mucoadhesive tablets to improve its low bioavailability and provide controlled release for the treatment of Parkinson's disease.