Optimization of piribedil mucoadhesive tablets for efficient therapy of Parkinson's disease: physical characterization and ex vivo drug permeation through buccal mucosa


Celik B. , Ozdemir S., Demirkoz A. B. , Uner M.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol.43, no.11, pp.1836-1845, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 11
  • Publication Date: 2017
  • Doi Number: 10.1080/03639045.2017.1349785
  • Title of Journal : DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Page Numbers: pp.1836-1845

Abstract

Objective: The aim of this study was optimization of buccal piribedil (PR) mucoadhesive tablets to improve its low bioavailability and provide controlled release for the treatment of Parkinson's disease.