In vitro α-glucosidase, docking and density functional theory studies on novel azide metal complexes

Avcı D., Özge Ö., Sönmez F., Tamer Ö., Başoğlu A., Atalay Y., ...Daha Fazla

Future Medicinal Chemistry, cilt.16, sa.11, ss.1109-1125, 2024 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 11
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1080/17568919.2024.2342650
  • Dergi Adı: Future Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1109-1125
  • Anahtar Kelimeler: azide, Cu/Hg/Cd/Ag/Zn ions, Schiff base, spectral elucidation, TD/DFT methods, α-glucosidase/docking
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Aim: The goal of this study is to synthesize new metal complexes containing N-methyl-1-(pyridin-2-yl)methanimine and azide ligands as α-glucosidase inhibitors for Type 2 diabetes. Materials & methods: The target complexes (12–16) were synthesized by reacting N-methyl-1-(pyridin-2-yl)methanimine (L1) with sodium azide in the presence of corresponding metal salts. The investigation of target protein interactions, vibrational, electronic and nonlinear optical properties for these complexes was performed by molecular docking and density functional theory studies. Results: Among these complexes, complex 13 (IC50 = 0.2802 ± 0.62 μM) containing Hg ion showed the highest α-glucosidase inhibitory property. On the other hand, significant results were detected for complexes containing Cu and Ag ions. Conclusion: Complex 13 may be an alternate anti-diabetic inhibitor according to in vitro/docking results.