The effects of melatonin in glutamate-induced neurotoxicity of rat cerebellar granular cell culture


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Gepdiremen A. A. , DUZENLI S., HACIMUFTUOGLU A., BULUCU D., SULEYMAN H.

JAPANESE JOURNAL OF PHARMACOLOGY, cilt.84, ss.467-469, 2000 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 84 Konu: 4
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1254/jjp.84.467
  • Dergi Adı: JAPANESE JOURNAL OF PHARMACOLOGY
  • Sayfa Sayısı: ss.467-469

Özet

In the present study, melatonin was tested in subsequent doses in glutamate induced neurotoxicity in cerebellar granular cell culture of rat pups. Glutamate at 10(-7) M was found to induce neuronal cell death. The dead cell score was 2.75 +/- 0.7 in the control, while it was found to be 35.12 +/- 1.8 in the glutamate-administered group (P<0.0001). Melatonin very potently blocked glutamate neurotoxicity at all doses tested, with 10(-3) M, the highest dose tested, being the most effective. Glutamate may exert a neuroprotective effect by blocking one or more steps of the oxidation cascade in neurons and this effect may be blocked by melatonin.