Reversible Corpus Callosum Splenial Lesion Due to Steroid Therapy

AKSU B., Kurtcan S. , Alkan A. , Aralasmak A. , OKTEM F.

JOURNAL OF NEUROIMAGING, cilt.25, sa.3, ss.501-504, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/jon.12128
  • Sayfa Sayıları: ss.501-504


Reversible corpus callosum splenial (CCS) lesions are rare findings and usually detected incidentally. We presented a case of 15-year-old boy with a diagnoses of nephrotic syndrome. He was referred for neuropsychiatric symptoms following dose reduction on steroid treatment. Brain magnetic resonance imaging (MRI) revealed a focal lesion in the CCS, hyperintense on T2 and FLAIR and hypointense on T1 images with diffusion restriction on apparent diffusion coefficient map. Follow-up MRI 3 weeks later showed complete resolution of the lesion. It was probably result of focal intramyelinic edema due to excytotoxic mechanisms and/or arginine-vasopressin release.