Reversible Corpus Callosum Splenial Lesion Due to Steroid Therapy

AKSU B., Kurtcan S. , Alkan A. , Aralasmak A. , OKTEM F.

JOURNAL OF NEUROIMAGING, vol.25, no.3, pp.501-504, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1111/jon.12128
  • Title of Journal : JOURNAL OF NEUROIMAGING
  • Page Numbers: pp.501-504


Reversible corpus callosum splenial (CCS) lesions are rare findings and usually detected incidentally. We presented a case of 15-year-old boy with a diagnoses of nephrotic syndrome. He was referred for neuropsychiatric symptoms following dose reduction on steroid treatment. Brain magnetic resonance imaging (MRI) revealed a focal lesion in the CCS, hyperintense on T2 and FLAIR and hypointense on T1 images with diffusion restriction on apparent diffusion coefficient map. Follow-up MRI 3 weeks later showed complete resolution of the lesion. It was probably result of focal intramyelinic edema due to excytotoxic mechanisms and/or arginine-vasopressin release.