Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways

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İLBEY Y. Ö., Ozbek E., ÇEKMEN M. B., Simsek A., Otunctemur A., Somay A.

HUMAN REPRODUCTION, vol.24, no.7, pp.1717-1725, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 7
  • Publication Date: 2009
  • Doi Number: 10.1093/humrep/dep058
  • Journal Name: HUMAN REPRODUCTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1717-1725
  • Keywords: curcumin, nitric oxide, NF-kB, cisplatin, testicular damage, NITRIC-OXIDE SYNTHASE, P38 MAPK INHIBITOR, ISCHEMIA/REPERFUSION INJURY, TRANSCRIPTION FACTOR, LIPID-PEROXIDATION, MESANGIAL CELLS, GROWTH-FACTOR, CROSS-TALK, TNF-ALPHA, EXPRESSION
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

The aim of this study was to investigate the cellular/biochemical mechanisms by which cisplatin (CIS) causes testicular toxicity. We evaluated the role of inducible nitric oxide synthase (iNOS) expression, mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kB) activation in the pathogenesis of testicular damage induced by CIS, and investigated the effects of curcumin (CMN) against CIS-induced testicular injury in rats.