Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways

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İLBEY Y. Ö., Ozbek E., ÇEKMEN M. B., Simsek A., Otunctemur A., Somay A.

HUMAN REPRODUCTION, cilt.24, sa.7, ss.1717-1725, 2009 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 7
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1093/humrep/dep058
  • Dergi Adı: HUMAN REPRODUCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1717-1725
  • Anahtar Kelimeler: curcumin, nitric oxide, NF-kB, cisplatin, testicular damage, NITRIC-OXIDE SYNTHASE, P38 MAPK INHIBITOR, ISCHEMIA/REPERFUSION INJURY, TRANSCRIPTION FACTOR, LIPID-PEROXIDATION, MESANGIAL CELLS, GROWTH-FACTOR, CROSS-TALK, TNF-ALPHA, EXPRESSION
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the cellular/biochemical mechanisms by which cisplatin (CIS) causes testicular toxicity. We evaluated the role of inducible nitric oxide synthase (iNOS) expression, mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kB) activation in the pathogenesis of testicular damage induced by CIS, and investigated the effects of curcumin (CMN) against CIS-induced testicular injury in rats.