Association between polymorphisms in HLA-A, HLA-B, HLA-DR, and DQ genes from gastric cancer and duodenal ulcer patients and cagL among cagA-positive Helicobacter pylori strains: The first study in a Turkish population


Kocak B., Saribas S., Demiryas S., Yilmaz E., Uysal Ö., Kepil N., ...More

Infection, Genetics and Evolution, vol.82, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 82
  • Publication Date: 2020
  • Doi Number: 10.1016/j.meegid.2020.104288
  • Journal Name: Infection, Genetics and Evolution
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: H. pylori, CagL, HLA, CagA, gastric cancer, duodenal ulcer, HUMAN-LEUKOCYTE ANTIGEN, CHRONIC ATROPHIC GASTRITIS, IV SECRETION, EPITHELIAL-CELLS, INFECTION, EXPRESSION, GENOTYPES, CARCINOMA, INTEGRIN, DISEASE

Abstract

Colonization of the human gastric mucosa by H. pylori may cause peptic and duodenal ulcers (DUs), gastric lymphomas, and gastric cancers. The cagL gene is a component of cag T4SS and is involved in cagA translocation into host. An association between the risk of gastric cancer and the type of HLA class II (DR and/or DQ) was suggested in different populations. The aim of this study was to investigate, the clinical association of the cagL gene with host HLA alleles in H. pylori strains that were isolated from patients with gastric cancer, DU, and non-ulcer dyspepsia (NUD) and to determine the HLA allele that confers susceptibility or resistance for the risk of gastric cancer and DU development in Turkish patients.