Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.

Hafız, AM; Doğan, REMZİ; Gucin, ZÜHAL; Ozer, Ömer; Yenigun, ALPER; Ozturan, ORHAN

doi:10.17219/acem/127682

Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.

Hafız A., Doğan R., Gucin Z., Ozer Ö. F., Yenigun A., Ozturan O.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University, cilt.29, sa.11, ss.1249-1254, 2020 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 29 Sayı: 11
Basım Tarihi: 2020
Doi Numarası: 10.17219/acem/127682
Dergi Adı: Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
Sayfa Sayıları: ss.1249-1254
Anahtar Kelimeler: antioxidant, tongue cancer, antitumoral, pyrrolidine dithiocarbamate, 4-nitroquinoline 1-oxide, NF-KAPPA-B, CARCINOGENESIS, ACTIVATION, INHIBITION, EXPRESSION, DAMAGE
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Background. Tongue tumors, which are oropharyngeal tumors, are increasing in frequency. Pyrrolidine dithiocarbamate (PDTC) is a powerful antioxidant and antitumoral agent. Objectives. To evaluate the protective and therapeutic effects of PDTC in a tongue cancer model induced with 4-nitroquinoline 1-oxide (4-NQO).