NEPHROTOXICITY OF GENTAMICIN AND COTRIMOXAZOLE COMBINATION IN RATS

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IZZETTIN F., AYCA B., URAS F., UYSAL V., CEVIKBAS U., YARDIMCI T., ...More

GENERAL PHARMACOLOGY, vol.25, no.6, pp.1185-1189, 1994 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 25 Issue: 6
• Publication Date: 1994
• Doi Number: 10.1016/0306-3623(94)90136-8
• Journal Name: GENERAL PHARMACOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1185-1189
• Bezmialem Vakıf University Affiliated: No

Abstract

1. The nephrotoxicity of gentamicin is well known. However, little information is available regarding the combined effects of gentamicin plus co-trimoxazole (sulfamethoxazole-trimethoprim). Therefore, Wistar rats were treated daily with 100 mg/kg gentamicin or 100 mg/kg gentamicin plus 30 mg/kg trimethoprim-150 mg/kg sulfamethoxazole for 14 days.