NEPHROTOXICITY OF GENTAMICIN AND COTRIMOXAZOLE COMBINATION IN RATS


IZZETTIN F. , AYCA B., URAS F., UYSAL V., CEVIKBAS U., YARDIMCI T., ...More

GENERAL PHARMACOLOGY, vol.25, no.6, pp.1185-1189, 1994 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 6
  • Publication Date: 1994
  • Doi Number: 10.1016/0306-3623(94)90136-8
  • Title of Journal : GENERAL PHARMACOLOGY
  • Page Numbers: pp.1185-1189

Abstract

1. The nephrotoxicity of gentamicin is well known. However, little information is available regarding the combined effects of gentamicin plus co-trimoxazole (sulfamethoxazole-trimethoprim). Therefore, Wistar rats were treated daily with 100 mg/kg gentamicin or 100 mg/kg gentamicin plus 30 mg/kg trimethoprim-150 mg/kg sulfamethoxazole for 14 days.