NEPHROTOXICITY OF GENTAMICIN AND COTRIMOXAZOLE COMBINATION IN RATS


IZZETTIN F. , AYCA B., URAS F., UYSAL V., CEVIKBAS U., YARDIMCI T., et al.

GENERAL PHARMACOLOGY, cilt.25, ss.1185-1189, 1994 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 25 Konu: 6
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0306-3623(94)90136-8
  • Dergi Adı: GENERAL PHARMACOLOGY
  • Sayfa Sayısı: ss.1185-1189

Özet

1. The nephrotoxicity of gentamicin is well known. However, little information is available regarding the combined effects of gentamicin plus co-trimoxazole (sulfamethoxazole-trimethoprim). Therefore, Wistar rats were treated daily with 100 mg/kg gentamicin or 100 mg/kg gentamicin plus 30 mg/kg trimethoprim-150 mg/kg sulfamethoxazole for 14 days.