Total synthesis of (+/-)-4 '-demethylmacrophyllol, a naturally occurring compound


GUENES M., Goeren A. C.

NATURAL PRODUCT RESEARCH, cilt.21, ss.362-365, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 21 Konu: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/14786410701194435
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Sayfa Sayısı: ss.362-365

Özet

The naturally occurring compound 4'-Demethylmacrophyllol (1), 8-Hydroxy- 3-(4-hydroxy-3,5-dimethoxy-phenyl)-isochroman-1-one, was synthesized starting from 4-benzyloxy-3,5-dimethoxybenzaldehyde (3) and a phosphonium salt (2) in four steps with an overall yield of 44%. This is the first report on the total synthesis of 4'-demethylmacrophyllol (1). The structures of compounds were determined by NMR and MS and elemental analysis techniques.