Total synthesis of (+/-)-4 '-demethylmacrophyllol, a naturally occurring compound


GUENES M., Goeren A. C.

NATURAL PRODUCT RESEARCH, vol.21, no.4, pp.362-365, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1080/14786410701194435
  • Title of Journal : NATURAL PRODUCT RESEARCH
  • Page Numbers: pp.362-365

Abstract

The naturally occurring compound 4'-Demethylmacrophyllol (1), 8-Hydroxy- 3-(4-hydroxy-3,5-dimethoxy-phenyl)-isochroman-1-one, was synthesized starting from 4-benzyloxy-3,5-dimethoxybenzaldehyde (3) and a phosphonium salt (2) in four steps with an overall yield of 44%. This is the first report on the total synthesis of 4'-demethylmacrophyllol (1). The structures of compounds were determined by NMR and MS and elemental analysis techniques.