Akademik Veri Yönetim Sistemi
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, cilt.16, ss.162-166, 2025 (ESCI)
Aim: Critical illness in the emergency department (ED) of a hospital requires rapid assessment and intervention. This study aimed to investigate the diagnostic and prognostic levels of D-lactate and SCUBE-1 in critically ill patients being admitted to the ED. Material and Methods: This prospective observational case-control study consisted of 45 critically ill patients and 45 healthy controls. Serum D-lactate and SCUBE-1 levels were measured upon admission to the ED, and clinical scores (APACHE II, GCS, RTS) were calculated for critically ill patients. The primary outcome was 28-day mortality. Results: Both D-lactate and SCUBE-1 levels were significantly higher in critically ill patients as compared to controls (p<0.001). In multivariate logistic regression analysis, SCUBE-1 (OR=2.16, 95%CI:1.65-3.43, p<0.001) and D-lactate (OR=1.86, 95%CI:1.11-2.41, p=0.012) were independent predictors of mortality. ROC analysis revealed that SCUBE-1 >43 ng/mL predicted mortality with 56.2% sensitivity and 72.4% specificity, while D-lactate >279 mmol/L showed 51.5% sensitivity and 68.3% specificity. D-lactate and SCUBE-1 levels are promising biomarkers for the prediction of mortality in critically ill ED patients. Discussion: These markers, when used in conjunction with clinical scoring systems, may prove useful when risk stratification and guide management decisions are made in the ED.