Evaluation of nasal fluid beta-defensin 2 levels in children with allergic rhinitis

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DILEK F., EMIN O., Gultepe B., Yazici M., Cakir E., GEDIK A. H.

TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS, vol.52, no.2, pp.79-84, 2017 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.5152/turkpediatriars.2017.4497
  • Journal Name: TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.79-84
  • Keywords: Allergic rhinitis, children, defensin, disease severity, nasal fluid, polyurethane, ANTIMICROBIAL PEPTIDES, HUMAN BETA-DEFENSIN-2, BRONCHOALVEOLAR LAVAGE, CATHELICIDIN, INNATE, IMMUNOTHERAPY, EXPRESSION, ASTHMA
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Aim: Knowledge about the role of the innate immune system in the pathogenesis of allergic diseases has been expanding in recent years. Defensins are antimicrobial peptides that are components of the innate immune system. Defensins have strong efficacy against bacterial, viral, and fungal infections. Moreover, they have regulatory functions in many physiologic processes such as antitumoral immunity, chemotaxis, inflammation, and wound healing. In this study, we aimed to investigate a-defensin 2 levels in the nasal fluids of children with allergic rhinitis.