Effect of nimesulide-on the indomethacin- and ibuprofen-induced ulcer in rat gastric tissue

SULEYMAN H., ALTINKAYNAK K., GOCER F., MARAS A., AKCAY F., ONUK M., ...More

POLISH JOURNAL OF PHARMACOLOGY, vol.54, no.3, pp.255-259, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 3
  • Publication Date: 2002
  • Journal Name: POLISH JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.255-259
  • Bezmialem Vakıf University Affiliated: No

Abstract

In this study, we examined the effect of nimesulide and ranitidine on the indomethacin- and ibuprofen-induced ulcer. In addition, we investigated whether there was a direct chemical interaction of nimesulide and ranitidine with indomethacin, and also whether nimesulide and ranitidine neutralized the gastric acid in vitro. Our studies showed that nimesulide (100, 300, 500 mg/kg) prevented the indomethacin-induced gastric ulcers completely. Ranitidine at a dose of 150 mg/kg reduced the mean ulcer area to 2.5 +/- 0.76 mm(2) in the indomethacin-treated and to 2.0 +/- 0.81 mm(2) in ibuprofen-treated rats. The mean ulcer areas in rats given only indomethacin and only ibuprofen were 20.3 +/- 1.58 mm(2). and 9.5 +/- 1.43 mm(2) respectively. There-were no chemical reactions between nimesulide and indomethacin or ranitidine and indomethacin in vitro. Nimesulide and ranitidine did riot neutralize the gastric acid in vitro.