Uluslararası Biyokimya Kongresi 2022 // 33. Ulusal Biyokimya Kongresi, İzmir, Turkey, 26 - 30 October 2022, vol.47, pp.137
OBJECTIVES: Gastric cancer is one of the most common types of gastrointestinal cancer worldwide and is the second most important cause of cancer-related deaths. Given the limitations in chemotherapy, radiotherapy, and surgical treatment, there is an increasing interest in complementary/alternative medicine approaches for gastric cancer. We aimed to compare the effects of heather honey and manuka honey, on gastric cancer.
MATERIALS and METHODS: The total phenolic and flavonoid content of manuka honeys with different MGO levels and heather honey were measured. Different concentrations of honey were applied to AGS cell line and viability analysis was performed using MTT method.
RESULTS: According to the findings, the total phenolic content was 13.5 for manuka 514MGO, 11.5 for manuka 300MGO, 8.5 for manuka 85MGO, 28.9 mgEqGallicacid/g for heather honey; total flavonoid content was found as 0.13, 0.35, 0.19, and 3.8 mgEqQuercetin/g, respectively. According to the MTT results, at different concentrations (0, 1, 10, 25, 50mg/ml) honey for 24 hours, the viability was determined as 61.9% for manuka 514MGO, 63.2% for manuka 300MGO, 71.2% for manuka 85MGO and 40.7% for heather honey at 50mg/ml concentration, respectively.
CONCLUSION: As a result, it was determined that the treatment of heather honey in gastric cancer cells was more effective than other manuka honeys. This is thought to be due to the fact that the total phenol and flavonoid content in heather honey is higher than manuka honeys. However, the mechanism underlying the cytotoxic effect and related signaling pathways need to be clarified with further studies.
Keywords: gastric cancer, honey, apitherapy.